ChE 415(E) DRUGS AND PHARMACEUTICAL TECHNOLOGY

Lectures: 4 periods/week Sessional Marks: 30
University Exam: 3 Hours University Examination Marks: 70


UNIT-I
A brief outline of grades of chemicals, sources of impurities in chemicals, principles (without going into details of individual chemicals) of limit test for arsenic, lead, iron, chloride and sulfate in pharmaceuticals.

UNIT-II
Outlines of preparation, properties, uses and testing of the following pharmaceuticals and fine chemicals, sulfacetamide, paracetamol, methyl orange, riboflavin, nicotinamide, fluoresence, procaine hydrochloride, paraamino salicylic acid, isonicatinic acid hydrazide.

UNIT-III
Manufacture with flow sheets, properties uses and testing of the following pharmaceuticals- aspirin, penicillin, calcium gluconate, ferric ammonium citrate, pthallic anhydride and phenol flourobenzene process and benzene sulfate process, other processes in outline only.

UNIT-IV
Sterilization: Introduction, risk factor, methods of sterilization, heat (dry and moist), heating with bactericide, filtration, gaseous sterilization and radiation sterilization, suitable example to be discussed and sterilization testing.


Text Books

  1. Text Book of Pharmaceutical chemistry, Blently and Driver, Oxford University Press, London, 8th Edition.

Reference Books
  1. Blently's Text Book of Pharmaceutical chemistry, E.A.Rawlins, B,Tindell and Box, 8th edition. O.U.Press, London
  2. Industrial Chemicals, Faith, Kayes and Clark, 3rd edition, John Wiley & Sons,
  3. Remington's Pharmaceutical science, 13th edition, Mac Publishing Company.